Attempts to Determine Whether the Secondary Reaction Is of Th~ Nature of an Arthus Phenomenon. By

In the preceding paper are described the lesions which follow the inoculation of certain non-hemolyt ic streptococci into the skin of the rabbit ; such lesions begin to decrease in size af ter 24 to 48 hours bu t in over 50 per cent of animals show a recrudescence of act iv i ty about the 8 th or 9th day. This phenomenon we have te rmed the secondary reaction. I t usually fails to occur in animals which have been previously inoculated with any var ie ty of streptococcus within a period of 9 weeks. Reasons have been given for a t t r ibut ing this secondary react ion ei ther to a toxic product of the streptococci which for some reason takes a number of days to exert its action, or more probably to an ant igen-ant ibody reaction, analogous perhaps to the Arthus phenomenon.